Basic Benchtop Freeze Dryer

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Basic Benchtop Freeze Dryer – QualiFD™ B Series

A Freeze Dryer in the QualiFD™ B Series helps labs remove solvents from frozen samples under vacuum for stable, dry storage. This Freeze Dryer Machine is a benchtop, basic platform built for routine freeze-drying across medicine, pharma, research, chemistry, and food applications.

The QualiFD™ B Series uses an integrated, compact design that fits common lab benches and reduces setup complexity. The cold trap and work surface use stainless steel construction to support cleaning and day-to-day lab use.

Materials in contact with product are described as inert for GLP-aligned workflows. A built-in pre-freeze approach supports routine runs without relying on a separate low-temperature freezer for many sample types. Control and monitoring are handled through an embedded touchscreen with real-time curves for key parameters.

This Freeze Dryer is a compact, basic Freeze Dryer Machine built for routine lyophilization in medicine, pharmaceuticals, biological research, chemistry, and food labs. It is designed for benchtop use with simple controls and a practical configuration selection so teams can match the setup to bulk samples, vial work, or ampoule drying.

Basic Benchtop Freeze Dryer – QualiFD™ B Series Applications

Pharmaceutical R&D sample preservation: Freeze-drying supports longer sample stability for formulations and intermediates that degrade in solution. Lab teams can dry small batches for screening and retain dried material for retest and transfer studies. The vacuum and temperature monitoring curves support repeatable process development workflows.
Biological research and biomaterials: Proteins, enzymes, cultures, and research reagents often benefit from low-moisture storage. Freeze-drying reduces water activity and helps maintain sample integrity during storage and shipping. The ampoule-tube configuration supports preservation of microorganisms such as bacteria and fungi.
Chemical labs and specialty materials: Labs freeze-dry chemical solutions, suspensions, and porous materials when low-temperature drying is preferred. A manifold configuration supports vials or bottles connected externally for drying and may be paired with concentration workflows when needed. This helps R&D teams manage multiple sample containers in parallel.
Food and ingredient development: Freeze-drying is used for pilot-scale R&D on ingredients, flavors, and sensitive components. It supports low-temperature drying where texture and volatile retention matter. Benchtop footprint helps early-stage product development teams run trials without large production systems.

Standards

ISO 13408-3: Aseptic processing of health care products, Part 3: Lyophilization (commonly referenced for lyophilization process and equipment expectations in controlled workflows).
ASTM E3250-21: Practice for product temperature and equipment pressure instrumentation in pharmaceutical freeze drying (useful reference for measurement and instrumentation practices).
21 CFR Part 11: Electronic records and electronic signatures (relevant when data export, audit trail, or electronic record practices are required).

Basic Benchtop Freeze Dryer – QualiFD™ B Series Key Features

Integrated benchtop build that reduces external connections and supports quick setup for routine lab runs.
Pre-freeze support through a large cold-trap opening and sample pre-freezing function for many workflows.
Stainless steel cold trap and work surface to support cleaning and day-to-day lab handling.

All-stainless venting valve design aimed at safety, corrosion resistance, and leak risk reduction.
	Even ice capture control using a gas flow control approach to improve cold-trap capture uniformity.
Touchscreen controller with real-time display and recording of cold-trap temperature, sample temperature, and vacuum curves, plus data export for review and printing. Alarm and protection logic covering operating-state alerts plus compressor and pump protection functions. Electric defrost function designed to shorten defrost time and simplify post-run cleanup.

Theory and Method

Freeze drying, also called lyophilization, removes solvent from a frozen sample by using vacuum and controlled heat. The process typically includes freezing, primary drying where ice sublimates, and secondary drying where bound moisture is reduced to reach a target residual level.

Cold trap temperature and chamber pressure influence the driving force for sublimation and the rate of vapor capture. Product temperature monitoring helps keep the sample below its critical temperature during primary drying. A final step returns the chamber to atmospheric pressure before unloading and sealing product.

Basic Benchtop Freeze Dryer – QualiFD™ B Series Technical Specification

Model configurations

QualiFD™ B1 (Standard): tray drying for bulk liquids, pastes, and solids.
QualiFD™ B2 (Top-press): tray drying plus vial drying support; pressure-cap sealing under vacuum for storage workflows.
QualiFD™ B3 (Standard + Manifolds): tray drying plus external hanging bottle attachment for vials or wide-mouth bottles.
QualiFD™ B4 (Top-press + Manifolds): combines top-press workflow with manifold capability.
QualiFD™ B5 (Ampoule tube): 24 ampoule tube interfaces for microorganism preservation workflows.

Specification	QualiFD™ B1	QualiFD™ B2	QualiFD™ B3	QualiFD™ B4	QualiFD™ B5
Configuration	Standard	Top-press	Standard + multiple manifolds	Top-press + multiple manifolds	Ampoule tube
Freeze drying area	0.12 m²	0.08 m²	0.12 m²	0.08 m²	—
Cold trap temperature	≤ -60 °C; options ≤ -80 °C; ≤ -110 °C (no-load)
Ultimate vacuum	< 5 Pa (no-load)
Water capture capacity	3–4 kg/24 h
Tray / shelves	Ø200 mm, 4 layers (opt. 6)	Ø180 mm, 3 layers	Ø200 mm, 4 layers (opt. 6)	Ø180 mm, 3 layers	—
Overall power	970 W
Main unit weight	41 kg
Dimensions (W×D×H)	615×450×370 mm + (430 drying chamber)				615×450×370 mm + (440)
Loadable materials (10 mm thickness references)	1.2 L/kg	0.8 L/kg	1.2 L/kg	0.8 L/kg	—
Vial capacity (tray-type reference)	Φ12 mm: 492 Φ16 mm: 279 Φ22 mm: 147	Φ12 mm: 492 Φ16 mm: 279 Φ22 mm: 147	Via external manifold setup (capacity depends on container set)	Via external manifold setup (capacity depends on container set)	Ampoule tube interfaces: 24

Operating Guide

Open System Menu → Operation Screen, then switch Compressor to On.
After pre-freezing, place the material into the drying chamber. Switch Vacuum Pump and Vacuum Gauge to On.
Before removing samples, fully open the inlet/exhaust (venting) valve and wait for the chamber and cold trap to return to atmospheric pressure. During shutdown, re-inflate first, then turn off the vacuum pump to help prevent oil backflow.
Press Defrost. Defrosting takes about 30 minutes. Keep the drain valve open, and place a container under the drain to collect water.

FAQ

Q1: Vacuum does not reach below 15 Pa. What should be checked first?

Check the vacuum pump connection to the main unit, the cleanliness and condition of the cover sealing surface, and whether the O

Q2: What if vacuum pump oil is leaking?

Inspect the machine body and replace the required parts based on the inspection findings.

Q3: Cold trap temperature is higher than expected. What are common causes?

Ambient temperature or poor ventilation can reduce heat dissipation. Check for dust on cooling fins and condenser surfaces, conf

Basic Benchtop Freeze Dryer

Basic Benchtop Freeze Dryer – QualiFD™ B Series