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Contactless Ultrasonic DNA Disruptor – QualiDNA™ CUD

Contactless Ultrasonic DNA Disruptor
Parent Product
Life Science Equipments
Standards
IEC 61010-1
IEC 61326-1
UL 61010-1
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Contactless Ultrasonic DNA Disruptor – QualiDNA™ CUD

Ultrasonic DNA Disruptor systems like QualiDNA™ CUD are built to shear DNA and fragment chromatin in sealed tubes without a probe touching the sample.

This contactless ultrasonic approach helps reduce aerosol risk and cross-contamination while supporting repeatable sample preparation for sequencing and ChIP workflows. The platform uses a temperature-controlled ultrasonic bath with programmable sonication and pause cycles for better control of fragment size distributions.

QualiDNA™ CUD is a contactless Ultrasonic DNA Disruptor designed for high-throughput, small-volume processing in life science labs. Samples stay closed in tube racks while ultrasound energy couples through the bath, supporting sterile handling and consistent processing across batches. A constant-temperature cooling system and precise temperature display help manage heat buildup during longer protocols.

Workflows can be tuned using total sonication time, on-time, off-time, and duty cycle settings. Frequency self-adaptation supports stable energy delivery across different rack formats and loading conditions. The result is a practical platform for labs that need standardized, repeatable DNA shearing and chromatin fragmentation.

Contactless Ultrasonic DNA Disruptor – QualiDNA™ CUD Applications

  • DNA shearing for NGS library preparation Prepare genomic DNA for next-generation sequencing by tuning cycle timing and duty cycle to target a desired fragment range. Closed-tube operation supports cleaner handling across multiple samples.
  • Chromatin fragmentation for ChIP assays Process chromatin immunoprecipitation samples with controlled sonication and temperature management to support consistent fragment profiles across runs.
  • Sterile, sealed-tube sample disruption Handle valuable or contamination-sensitive samples in sealed vessels to reduce sample-to-sample carryover that can happen with direct-probe contact.
  • High-throughput small-volume processing Run tube racks for micro-volume samples to improve workflow efficiency when multiple samples must be processed in a single session.
Contactless Ultrasonic DNA Disruptor – QualiDNA™ CUD

Standards

  • IEC 61010-1 (Safety requirements for electrical equipment for measurement, control, and laboratory use).
  • IEC 61326-1 (EMC requirements for electrical equipment for measurement, control, and laboratory use).
  • UL 61010-1 / CSA equivalents are often used for North American safety certification pathways when required.

Contactless Ultrasonic DNA Disruptor – QualiDNA™ CUD Key Features

  • Probe-free, sealed processing that supports low carryover risk between samples.
  • High power output with adjustable control for protocol flexibility across sample types.
  • Programmable total time, work time, and interval time to tune fragmentation and manage heating.
  • Frequency self-adaptation for stable operation under different loading conditions.
  • Independent constant-temperature cooling system with fine temperature display resolution.
  • Rack-based throughput for micro-volume tubes and multi-sample batches.

Theory and Method

Contactless sonication transfers ultrasonic energy through a liquid bath into sealed sample tubes. Ultrasound generates cavitation in the bath, creating localized shear forces that disrupt biomolecular structures and drive DNA/chromatin fragmentation. Because the probe does not enter the sample, handling remains cleaner and repeatability improves across multi-sample racks.

Contactless Ultrasonic DNA Disruptor – QualiDNA™ CUD

A typical method uses three core controls:

  • Total time to set overall energy delivered.
  • On/Off cycles to manage heat and tune fragmentation behavior.
  • Duty cycle and power to adjust intensity and throughput.

Temperature control supports stable conditions during longer protocols, which (for DNA and chromatin workflows) helps maintain run-to-run consistency.

Contactless Ultrasonic DNA Disruptor – QualiDNA™ CUD Technical Specification

ItemQualiDNA™ CUD
Power2500 W, adjustable (0–100%)
FrequencyAuto-adaptive (listed as 20–400 kHz)
Total ultrasonic time0.1 s to 199 h 59 m 59.9 s (adjustable)
Ultrasonic working time (on-time)0.1 s to 99.9 s (adjustable)
Ultrasonic intermittent time (off-time)0 s to 99.9 s (0 = continuous mode)
Duty cycle0.1% to 99.9%
Ultrasonic tank volume3.3 L
Sample processing capacityUp to 60 samples of 0.1 mL (max capacity listed)
Adapter (examples)Multiple tube rack formats listed; additional racks optional
Operating voltage / frequency220 V / 50 Hz (listed) (110V is also available)
Temperature control range2–40 °C (listed)
Temperature display accuracy0.1 °C
Cooling systemIndependent constant-temperature tank main unit (listed)

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